The noncontact spectrophotometric intracutaneous analysis scope (SIAscope) is a novel portable imaging device that rapidly produces images of the blood and melanin content of large areas of skin. The estimation of burn depth is often difficult in the clinical setting, and this pilot study was conducted to assess the potential for the SIAscope in aiding burn assessment. Nine patients with a variety of burn injuries had images taken of their acute burns within 48 hours of injury, both with a noncontact SIAscope and a laser Doppler perfusion imaging system (LDPI). Results showed that superficial partial thickness burns had increased hemoglobin and loss of melanin on SIAgraphs, whereas deep partial thickness burns had more pronounced hemoglobin concentrations and apparent melanin increases, helping to differentiate these 2 burn types. The SIAscope, a relatively inexpensive, portable device, has the potential to be a highly useful clinical adjunct in the bedside estimation of acute burn depth.