Epithelial-immune cell interaction in dry eye

Cornea. 2008 Sep;27 Suppl 1(0 1):S9-11. doi: 10.1097/ICO.0b013e31817f4075.


Dry eye is a potent stimulus of both innate and adaptive immune systems. At the nexus of the dry eye inflammatory/immune response is the dynamic interplay between the ocular surface epithelia and the bone marrow-derived immune cells. On the one hand, ocular surface epithelial cells play a key initiating role in this inflammatory reaction. On the other hand, they are targets of cytokines produced by activated T cells that are recruited to the ocular surface in response to dry eye. This interaction between epithelial and immune cells in dry eye will be thoroughly reviewed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibody Formation
  • Bone Marrow Cells / immunology
  • Cytokines / metabolism
  • Dry Eye Syndromes / complications
  • Dry Eye Syndromes / immunology
  • Dry Eye Syndromes / physiopathology*
  • Dry Eye Syndromes / therapy
  • Epithelial Cells
  • Eye / immunology
  • Eye / pathology
  • Eye / physiopathology*
  • Humans
  • Immune System / physiopathology
  • Inflammation / etiology


  • Cytokines