[Pharmacological treatment of pulmonary hypertension in patients with congenital heart disease]

Dtsch Med Wochenschr. 2008 Oct;133 Suppl 6:S209-11. doi: 10.1055/s-0028-1091241. Epub 2008 Sep 23.
[Article in German]


The development of drugs for lowering pressures in pulmonary arterial hypertension (PHT) has provided possible therapeutic application in patients with pulmonary hypertension associated with congenital heart disease (CHD). Prostanoids, both nonselective and selective endothelin-receptor antagonists and phosphodiesterase-V inhibitors have been used for this purpose. The efficacy of these drugs - from different classes of bioactivity - in this context have been shown in several studies. However, the long-term effects of drug treatment on prognosis and course of PHT have not yet been adequately investigated. The current status of drug treatment of PHT in patients with CHD is reviewed in this article.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Antihypertensive Agents / therapeutic use
  • Endothelin Receptor Antagonists*
  • Heart Defects, Congenital / complications*
  • Humans
  • Hypertension, Pulmonary / complications
  • Hypertension, Pulmonary / drug therapy*
  • Phosphodiesterase 5 Inhibitors*
  • Phosphodiesterase Inhibitors / therapeutic use
  • Prostaglandins / therapeutic use*
  • Randomized Controlled Trials as Topic
  • Vasodilator Agents / therapeutic use


  • Antihypertensive Agents
  • Endothelin Receptor Antagonists
  • Phosphodiesterase 5 Inhibitors
  • Phosphodiesterase Inhibitors
  • Prostaglandins
  • Vasodilator Agents