The B-cell antigen receptor of the five immunoglobulin classes

Nature. 1991 Aug 29;352(6338):777-81. doi: 10.1038/352777a0.

Abstract

Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the alpha and beta associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, a common alpha chain associates with all five immunoglobulin classes. We propose that B-cell antigen receptors consist of a common alpha/beta heterodimer associated with each immunoglobulin class. But the classes differ both in the glycosylation of their associated alpha chain and in their dependence on alpha/beta for surface transport.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Line
  • DNA / genetics
  • Fibroblasts / immunology
  • Glycosylation
  • Immunoglobulin A / metabolism
  • Immunoglobulin D / genetics
  • Immunoglobulin D / metabolism
  • Immunoglobulin E / metabolism
  • Immunoglobulin G / metabolism
  • Immunoglobulin M / metabolism*
  • Macromolecular Substances
  • Mice
  • Molecular Sequence Data
  • Plasmacytoma / immunology
  • Receptors, Antigen, B-Cell / chemistry
  • Receptors, Antigen, B-Cell / genetics
  • Receptors, Antigen, B-Cell / immunology*
  • Transfection
  • Tumor Cells, Cultured

Substances

  • Immunoglobulin A
  • Immunoglobulin D
  • Immunoglobulin G
  • Immunoglobulin M
  • Macromolecular Substances
  • Receptors, Antigen, B-Cell
  • Immunoglobulin E
  • DNA