The effect of EC-IC bypass surgery on resting cerebral blood flow and cerebrovascular reserve capacity studied with stable XE-CT and acetazolamide test

Neuroradiology. 1991;33(3):217-22. doi: 10.1007/BF00588221.


Cerebral blood flow (CBF) and cerebrovascular reserve capacity (CRC) were measured by stable xenon computerized tomography (Xe-CT) and acetazolamide test in 15 patients with cerebrovascular disease before and after extracranial-intracranial (EC-IC) bypass surgery for minor stroke, reversible ischemic neurological deficit or transient ischemic attack. All had angiographically shown occlusive lesions of the major arterial trunk. In the present series, global analysis showed that the bypass did not increase the resting rCBF, but did increase the rCRC. We divided the patients into four groups according to the preoperative resting rCBF and rCRC. All 3 patients with normal resting rCBF and reduced rCRC showed postoperative improvement of rCRC. Of 6 patients with reduced CBF and reduced CRC, three had postoperative increase in resting CBF and four had increased CRC. One of two patients with reduced CBF and normal CRC showed only an increase in CRC. We propose that reduced CRC or reduced CBF with reduced CRC are criteria for selection of candidates for bypass surgery. We conclude that Xe-CT with the Diamox test is a useful and simple method for evaluating cerebral hemodynamics. Preoperative grouping with a combination of preoperative resting rCBF and preoperative rCRC is useful for predicting the effect of EC-IC bypass surgery.

Publication types

  • Case Reports

MeSH terms

  • Acetazolamide*
  • Aged
  • Brain / diagnostic imaging
  • Brain Ischemia / diagnostic imaging
  • Brain Ischemia / physiopathology
  • Brain Ischemia / surgery
  • Cerebral Angiography
  • Cerebral Revascularization*
  • Cerebrovascular Circulation* / drug effects
  • Female
  • Humans
  • Male
  • Middle Aged
  • Tomography, X-Ray Computed*
  • Xenon*


  • Xenon
  • Acetazolamide