Neutrophil as a mediator of ischemic edema formation in the brain

Neurosci Lett. 1991 Apr 29;125(2):110-2. doi: 10.1016/0304-3940(91)90003-c.


We investigated the contribution of neutrophils to brain edema formation using a transient focal ischemia model in rats. Rats were given anti-neutrophil monoclonal antibody (RP3) intraperitoneally to deplete circulating neutrophils. In RP3-treated rats, ischemic brain edema formation 1 day after reperfusion was significantly decreased compared to that of saline-treated control rats. We speculate that chemical mediators released by infiltrating neutrophils alter vascular permeability and play an important role in post-ischemic brain edema formation.

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Body Water / chemistry
  • Brain Edema / pathology
  • Brain Edema / physiopathology*
  • Ischemic Attack, Transient / pathology
  • Ischemic Attack, Transient / physiopathology*
  • Male
  • Neutrophils / pathology
  • Neutrophils / physiology*
  • Rats
  • Rats, Inbred Strains
  • Reperfusion
  • Time Factors


  • Antibodies, Monoclonal