The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus

Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):150-6. doi: 10.1111/j.1742-7843.2008.00253.x.


The effect of cannabinoids on motion-induced emesis is unknown. The present study investigated the action of phytocannabinoids against motion-induced emesis in Suncus murinus. Suncus murinus were injected intraperitoneally with either cannabidiol (CBD) (0.5, 1, 2, 5, 10, 20 and 40 mg/kg), Delta(9)-tetrahydrocannabinol (Delta(9)-THC; 0.5, 3, 5 and 10 mg/kg) or vehicle 45 min. before exposure to a 10-min. horizontal motion stimulus (amplitude 40 mm, frequency 1 Hz). In further investigations, the CB(1) receptor antagonist, N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM 251; 5 mg/kg), was injected 15 min. prior to an injection of Delta(9)-THC (3 mg/kg). The motion stimulus was applied 45 min. later. The number of emetic episodes and latency of onset to the first emetic episode were recorded. Pre-treatment with the above doses of CBD did not modify the emetic response to the motion stimulus as compared to the vehicle-treated controls. Application of the higher doses of Delta(9)-THC induced emesis in its own right, which was inhibited by AM 251. Furthermore, pre-treatment with Delta(9)-THC dose-dependently attenuated motion-induced emesis, an effect that was inhibited by AM 251. AM 251 neither induced an emetic response nor modified motion-induced emesis. The present study indicates that Delta(9)-THC, acting via the CB(1) receptors, is anti-emetic to motion, and that CBD has no effect on motion-induced emesis in Suncus murinus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiemetics / pharmacology
  • Antiemetics / therapeutic use*
  • Cannabidiol / pharmacology
  • Cannabidiol / therapeutic use*
  • Disease Models, Animal*
  • Dose-Response Relationship, Drug
  • Dronabinol / pharmacology
  • Dronabinol / therapeutic use*
  • Motion Sickness / complications
  • Motion Sickness / metabolism
  • Motion Sickness / prevention & control*
  • Receptor, Cannabinoid, CB1 / metabolism
  • Shrews*
  • Vestibule, Labyrinth / drug effects
  • Vomiting / etiology
  • Vomiting / metabolism
  • Vomiting / prevention & control*


  • Antiemetics
  • Receptor, Cannabinoid, CB1
  • Cannabidiol
  • Dronabinol