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. 2008 Sep;5(9):1675-82.
doi: 10.1002/cbdv.200890156.

Dendritic Nucleotides: Interaction With an Aliphatic Acid Monolayer

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Dendritic Nucleotides: Interaction With an Aliphatic Acid Monolayer

Guojie Wang et al. Chem Biodivers. .

Abstract

Dendrimeric-T and dendrimeric-A with 36 nucleotides were synthesized using phosphoramidite reagents. These dendrimers contain the nucleosides dA and dT, which are the components of the dA-dT base pair. Branching was obtained using a bifurcated and trifurcated reagent. The dendrimers were purified by ion-exchange chromatography. No specific interactions between these dendrimers were observed using atomic force microscopy. However, the dendrimeric-T is able to disrupt monolayers of fatty acids, resulting in a reorientation of the lipids (from head-to-tail to head-to-head) as demonstrated by scanning tunneling microscopy (STM).

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