Dendritic nucleotides: interaction with an aliphatic acid monolayer

Chem Biodivers. 2008 Sep;5(9):1675-82. doi: 10.1002/cbdv.200890156.


Dendrimeric-T and dendrimeric-A with 36 nucleotides were synthesized using phosphoramidite reagents. These dendrimers contain the nucleosides dA and dT, which are the components of the dA-dT base pair. Branching was obtained using a bifurcated and trifurcated reagent. The dendrimers were purified by ion-exchange chromatography. No specific interactions between these dendrimers were observed using atomic force microscopy. However, the dendrimeric-T is able to disrupt monolayers of fatty acids, resulting in a reorientation of the lipids (from head-to-tail to head-to-head) as demonstrated by scanning tunneling microscopy (STM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Dendrimers / chemistry*
  • Fatty Acids / chemistry*
  • Microscopy, Atomic Force
  • Microscopy, Scanning Tunneling
  • Molecular Structure
  • Nucleotides / chemical synthesis
  • Nucleotides / chemistry*


  • Dendrimers
  • Fatty Acids
  • Nucleotides