A simple cytosine to G-clamp nucleobase substitution enables chiral gamma-PNAs to invade mixed-sequence double-helical B-form DNA

Chembiochem. 2008 Oct 13;9(15):2388-91. doi: 10.1002/cbic.200800441.

Abstract

Watson-Crick recognition of double helical B-form DNA by chiral γ-PNAs: C→G-clamp nucleobase substitution provides the necessary energetics for chiral γ-PNAs to invade mixed-sequence B-DNA

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Circular Dichroism
  • Cytosine / chemistry*
  • DNA / chemistry*
  • Guanosine / chemistry*
  • Nucleic Acid Conformation*
  • Peptide Nucleic Acids / chemistry*
  • Stereoisomerism

Substances

  • Peptide Nucleic Acids
  • Guanosine
  • Cytosine
  • DNA