Polymeric PARACEST agents for enhancing MRI contrast sensitivity

J Am Chem Soc. 2008 Oct 22;130(42):13854-5. doi: 10.1021/ja805775u. Epub 2008 Sep 26.


Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chelating Agents / chemical synthesis
  • Chelating Agents / chemistry*
  • Contrast Media / chemical synthesis
  • Contrast Media / chemistry*
  • Europium / chemistry
  • Image Enhancement / methods*
  • Magnetic Resonance Imaging / methods*
  • Magnetics*
  • Molecular Structure
  • Polymers / chemical synthesis
  • Polymers / chemistry*
  • Sensitivity and Specificity


  • Chelating Agents
  • Contrast Media
  • Polymers
  • Europium