Vitamin E dependent microRNA regulation in rat liver

FEBS Lett. 2008 Oct 15;582(23-24):3542-6. doi: 10.1016/j.febslet.2008.09.032. Epub 2008 Sep 24.


Dietary vitamin E (VE) is known to regulate gene expression by altering mRNA concentrations. Recently, microRNA (miRNA) have been discovered as a means of posttranscriptional gene regulation. Since the effect of VE on miRNA regulation is unknown, we fed rats for 6 months diets deficient or sufficient in VE and determined hepatic concentrations of miRNA involved in processes previously associated with VE (lipid metabolism, miRNA-122a; cancer and inflammation, miRNA-125b). VE-deficiency resulted in reduced concentrations of miRNA-122a and miRNA-125b. The findings of the present study demonstrate that differences in dietary VE may affect hepatic miRNA concentrations in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cell Transformation, Neoplastic / genetics
  • Diet
  • Gene Expression Regulation / drug effects
  • Inflammation / genetics
  • Lipid Metabolism / drug effects
  • Lipid Metabolism / genetics
  • Liver / drug effects
  • Liver / metabolism*
  • Male
  • MicroRNAs / metabolism*
  • Rats
  • Rats, Inbred F344
  • Vitamin E / administration & dosage
  • Vitamin E / metabolism*
  • Vitamin E / pharmacology


  • MicroRNAs
  • Vitamin E