Family history and age at onset of breast cancer in Hispanic and non-Hispanic white women

Cancer Causes Control. 2008 Dec;19(10):1349-55. doi: 10.1007/s10552-008-9206-x. Epub 2008 Sep 26.


Objectives: To evaluate the association between family history of breast cancer and breast cancer risk among Hispanic and non-Hispanic white (NHW) women.

Methods: Logistic regression models were used to compute unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) using data collected from the 4-Corners Breast Cancer Study, a population-based case-control study of breast cancer conducted in the Southwest United States (3,074 NHW and 1,647 Hispanic women).

Results: The association between family history of breast cancer and early-onset breast cancer risk differs among NHW and Hispanic women. Among women <50 years old, having a family history of breast cancer was associated with a greater increase in risk among NHWs, with an OR of 2.34 (95% CI: 1.64-3.35) when compared to an OR of 1.32 (95% CI: 0.82-2.19) for Hispanics. This difference in risk was not observed among women 50 years and older, with an OR of 1.69 (95% CI: 1.34-2.13) for NHW and 1.47 (95% CI: 1.03-2.10) for Hispanics.

Conclusions: Family history of breast cancer poses a greater risk for early-onset breast cancers among NHW when compared to Hispanic women and may reflect ethnic differences in certain predisposing genetic factors that promote breast cancer development.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Age Factors
  • Age of Onset
  • Aged
  • Breast Neoplasms / epidemiology*
  • Breast Neoplasms / ethnology*
  • Breast Neoplasms / genetics
  • Case-Control Studies
  • Confidence Intervals
  • Confounding Factors, Epidemiologic
  • European Continental Ancestry Group / statistics & numerical data*
  • Family Health / ethnology*
  • Female
  • Genetic Predisposition to Disease
  • Hispanic Americans / statistics & numerical data*
  • Humans
  • Incidence
  • Interviews as Topic
  • Logistic Models
  • Middle Aged
  • Odds Ratio
  • Risk Factors
  • Surveys and Questionnaires
  • United States / epidemiology
  • United States / ethnology