[Effect of mexidol on the magnitude of a systemic inflammatory response in patients at aortocoronary bypass surgery]

Anesteziol Reanimatol. 2008 Jul-Aug:(4):27-30.
[Article in Russian]


Objective: to evaluate the efficiency of pharmacological correction of a systemic inflammatory response in patients after coronary bypass surgery, by using mexidol.

Subjects and methods: 40 patients with coronary heart disease, who had undergone myocardial revascularization were examined. A study group (n = 20) received mexidol within 5 days before, during, and 5 days after surgery. A control group (n = 20) were given 0.9% NaCl solution. The degree of a systemic inflammatory response was estimated from the levels of C-reactive protein (CRP), the cytokines IL-6, IL-8, and TNF-alpha. The activities of serum enzymes and myoglobin were determined.

Results: after surgery, both groups showed the elevated concentrations of IL-6, IL-8, TNF-alpha, and CRP, but their elevation was statistically significant less in the study group than in the control one (p < 0.05). In both groups, there were increases in the levels of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, lactate dehydrogenase, creatinine phosphokinase, and myoglobin, which was statistically significant more apparent in the control group (p < 0.05).

Conclusions: mexidol diminishes the magnitude of a systemic response after aortocoronary bypass surgery under extracorporeal circulation and has an organ-protective effect.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Coronary Artery Bypass*
  • Coronary Disease / surgery
  • Cytokines / immunology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Picolines / administration & dosage
  • Picolines / pharmacology
  • Picolines / therapeutic use*
  • Postoperative Complications / etiology
  • Postoperative Complications / immunology
  • Postoperative Complications / metabolism
  • Postoperative Complications / prevention & control*
  • Reactive Oxygen Species / metabolism
  • Systemic Inflammatory Response Syndrome / etiology
  • Systemic Inflammatory Response Syndrome / immunology
  • Systemic Inflammatory Response Syndrome / metabolism
  • Systemic Inflammatory Response Syndrome / prevention & control*
  • Time Factors


  • Antioxidants
  • Cytokines
  • Picolines
  • Reactive Oxygen Species
  • emoxypine succinate