Ginkgo Biloba preparations exhibit nootropic activity in the absence of side effects, which is confirmed by numerous experimental observations and clinical results. The neuroprotector effect of these drugs is based on the antitoxicant action, antioxidant properties, and the ability to normalize the neuromediator and energy transfer mechanisms in cerebral neurons. In this review, recent data on the influence of various Ginkgo Biloba preparations on the cognitive functions in animals and humans and neurochemical mechanisms of the nootropic effect are summarized.