[Bilateral leg compartment syndrome due to severe myonecrosis caused by inappropriate use of simvastatin]

J Mal Vasc. 2008 Dec;33(4-5):229-33. doi: 10.1016/j.jmv.2008.07.092. Epub 2008 Sep 25.
[Article in French]


Bilateral leg compartment syndrome due to myonecrosis caused by inappropriate use of statins is a rare but potentially fatal complication of this lipid lowering medication. We report a case of a 39-year-old woman who presented with suspicious critical lower limb ischemia. Subsequently, bilateral leg compartment syndrome and myonecrosis developed. The primary cause of myonecrosis was due to misuse of simvastatin mistaken by the patient for a weight-reducing drug. Urgent fasciotomies were performed and the patient underwent urgent renal replacement therapy with continuous hemodialysis for acute renal failure due to myoglobinuria. After this complex treatment, the patient was discharged. She almost fully recovered with only a residual paresis of the left fibular nerve. According to literature, this is a unique case of bilateral compartment syndrome and myonecrosis with acute renal failure due to statin overdose leading to acute renal failure and bilateral fasciotomy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alanine Transaminase / blood
  • Anterior Compartment Syndrome / diagnostic imaging
  • Anterior Compartment Syndrome / etiology*
  • Aspartate Aminotransferases / blood
  • C-Reactive Protein / metabolism
  • Creatinine / blood
  • Female
  • Fibula / diagnostic imaging
  • Fibula / innervation
  • Functional Laterality
  • Humans
  • Ischemia / diagnostic imaging
  • Ischemia / etiology
  • Leg / blood supply
  • Muscle, Skeletal / diagnostic imaging
  • Muscular Diseases / chemically induced
  • Muscular Diseases / complications*
  • Muscular Diseases / surgery
  • Myoglobin / blood
  • Myoglobinuria / etiology
  • Simvastatin / adverse effects*
  • Tibia / diagnostic imaging
  • Tomography, X-Ray Computed
  • Treatment Outcome


  • Myoglobin
  • C-Reactive Protein
  • Simvastatin
  • Creatinine
  • Aspartate Aminotransferases
  • Alanine Transaminase