Specialized neuronal adaptation for preserving input sensitivity

Nat Neurosci. 2008 Nov;11(11):1259-61. doi: 10.1038/nn.2201. Epub 2008 Sep 28.


Some neurons in auditory cortex respond to recent stimulus history by adapting their response functions to track stimulus statistics directly, as might be expected. In contrast, some neurons respond to loud sounds by adjusting their response functions away from high intensities and consequently remain sensitive to softer sounds. In marmoset monkey auditory cortex, the latter type of adaptation appears to exist only in neurons tuned to stimulus intensity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation / methods
  • Action Potentials / physiology
  • Adaptation, Physiological / physiology*
  • Animals
  • Auditory Cortex / cytology*
  • Auditory Threshold / physiology*
  • Callithrix
  • Patch-Clamp Techniques / methods
  • Probability
  • Psychoacoustics
  • Sensory Receptor Cells / physiology*
  • Wakefulness