Origin of correlated activity between parasol retinal ganglion cells

Nat Neurosci. 2008 Nov;11(11):1343-51. doi: 10.1038/nn.2199. Epub 2008 Sep 28.


Cells throughout the CNS have synchronous activity patterns; that is, a cell's probability of generating an action potential depends both on its firing rate and on the occurrence of action potentials in surrounding cells. The mechanisms producing synchronous or correlated activity are poorly understood despite its prevalence and potential effect on neural coding. We found that neighboring parasol ganglion cells in primate retina received strongly correlated synaptic input in the absence of modulated light stimuli. This correlated variability appeared to arise through the same circuits that provide uncorrelated synaptic input. In addition, ON, but not OFF, parasol cells were coupled electrically. Correlated variability in synaptic input, however, dominated correlations in the parasol spike outputs and shared variability in the timing of action potentials generated by neighboring cells. These results provide a mechanistic picture of how correlated activity is produced in a population of neurons that are critical for visual perception.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Computer Simulation
  • Electric Stimulation / methods
  • In Vitro Techniques
  • Light
  • Macaca fascicularis
  • Macaca nemestrina
  • Models, Neurological
  • Nerve Net / cytology
  • Nerve Net / physiology*
  • Papio anubis
  • Patch-Clamp Techniques / methods
  • Photic Stimulation / methods
  • Retina / cytology*
  • Retinal Ganglion Cells / classification
  • Retinal Ganglion Cells / physiology*
  • Synapses / physiology