Tedanolide and the evolution of polyketide inhibitors of eukaryotic protein synthesis

Nat Prod Rep. 2008 Oct;25(5):854-61. doi: 10.1039/b805700c. Epub 2008 Jul 10.

Abstract

This Highlight covers the chemical and biological studies regarding a set of polyketide inhibitors of eukaryotic protein synthesis related to the marine-derived cytotoxic agent tedanolide.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Macrolides / chemical synthesis*
  • Macrolides / chemistry
  • Marine Toxins / chemical synthesis*
  • Marine Toxins / chemistry
  • Molecular Structure
  • Polyketide Synthases / metabolism*
  • Porifera / chemistry*
  • Protein Biosynthesis / drug effects*

Substances

  • Macrolides
  • Marine Toxins
  • Polyketide Synthases
  • tedanolide