Scaffold diversity of natural products: inspiration for combinatorial library design

Nat Prod Rep. 2008 Oct;25(5):892-904. doi: 10.1039/b715668p. Epub 2008 Jul 7.


Natural products contain scaffold structures that can be systematically exploited for the design of combinatorial compound libraries with druglike properties. We review approaches for scaffold identification, and compare properties and pharmacophoric features of drugs and natural products. In particular, an application of the self-organizing map technique is presented for natural product-derived compound and library design.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biological Products*
  • Combinatorial Chemistry Techniques*
  • Drug Design*
  • Molecular Structure


  • Biological Products