Clerodane diterpenoids with NGF-potentiating activity from Ptychopetalum olacoides

J Nat Prod. 2008 Oct;71(10):1760-3. doi: 10.1021/np8004002. Epub 2008 Sep 27.

Abstract

Four new clerodane-type diterpenoids, ptychonolide (1), 20-O-methylptychonal acetal (2), and an equilibrium mixture of ptychonal hemiacetal (3) and ptychonal (4), were isolated from the MeOH extract of the bark of a Brazilian plant, Ptychopetalum olacoides. The structure of 1 was elucidated as a clerodane-type diterpenoid on the basis of spectroscopic data, whereas 2 was assigned to an acetal derivative of 1. Compounds 3 and 4 existed as an equilibrium mixture. A mixture of compounds 3 and 4 was found to exhibit neurite outgrowth-promoting activities on NGF-mediated PC12 cells at concentrations ranging from 0.1 to 10.0 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brazil
  • Diterpenes, Clerodane* / chemistry
  • Diterpenes, Clerodane* / isolation & purification
  • Diterpenes, Clerodane* / pharmacology
  • Dose-Response Relationship, Drug
  • Molecular Structure
  • Nerve Growth Factor / agonists*
  • Neurites / drug effects*
  • Olacaceae / chemistry*
  • PC12 Cells
  • Plants, Medicinal / chemistry*
  • Rats

Substances

  • Diterpenes, Clerodane
  • Nerve Growth Factor