Preparation, characterization, and evaluation of radiopaque hydrogel filaments for endovascular embolization

J Biomed Mater Res B Appl Biomater. 2009 May;89(2):306-13. doi: 10.1002/jbm.b.31217.

Abstract

Radiopaque hydrogel filaments were prepared, characterized, and evaluated for potential use as implants for endovascular embolization of vascular defects. Three hydrogel formulations were prepared by free radical polymerization: (i) poly(ethylene glycol) diacrylate with 2,4,6-triiodophenyl penta-4-enoate (PEG-I), (ii) poly(ethylene glycol) diacrylamide with barium sulfate (PEG-B), and (iii) poly(propylene glycol) diacrylate with barium sulfate (PPG-B). The PEG-B and PPG-B hydrogels exhibited radiopacity comparable with clinically used platinum coils, whereas the PEG-I hydrogel did not. In the dry state, the average ultimate tensile strength and strain of the hydrogels ranged from 37 to 128 gf and 21% to 72%, respectively. The PEG-B hydrogel had significantly higher tensile strength compared with the PEG-I hydrogel. In the hydrated state, the average ultimate tensile strength and strain ranged from 5 to 15 gf and 7% to 30%, respectively. Statistically significant differences in tensile strength were not present when hydrated. Compared with poly(ethylene) after 4-week implantation into the subcutaneous space of rabbits, the PEG-I hydrogel elicited slightly more inflammation, whereas the PEG-B and PPG-B hydrogels elicited less inflammation. All three hydrogel formulations elicited less fibrous encapsulation than poly(ethylene). With further development, these materials have potential as embolization devices.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamides / chemistry
  • Acrylates / chemistry
  • Animals
  • Barium Sulfate / chemistry
  • Biocompatible Materials / chemistry*
  • Embolization, Therapeutic / instrumentation*
  • Giant Cells, Foreign-Body / immunology
  • Giant Cells, Foreign-Body / pathology
  • Humans
  • Hydrogels / chemistry*
  • Materials Testing
  • Polyethylene Glycols / chemistry
  • Polymers / chemistry
  • Propylene Glycols / chemistry
  • Rabbits
  • Tensile Strength

Substances

  • Acrylamides
  • Acrylates
  • Biocompatible Materials
  • Hydrogels
  • Polymers
  • Propylene Glycols
  • polypropylene glycol
  • Barium Sulfate
  • Polyethylene Glycols