Chronic granulomatous disease as a risk factor for autoimmune disease

J Allergy Clin Immunol. 2008 Dec;122(6):1097-103. doi: 10.1016/j.jaci.2008.07.050. Epub 2008 Sep 26.


Chronic granulomatous disease (CGD) is characterized by recurrent infections and granuloma formation. In addition, we have observed a number of diverse autoimmune conditions in our CGD population, suggesting that patients with CGD are at an elevated risk for development of autoimmune disorders. In this report, we describe antiphospholipid syndrome, recurrent pericardial effusion, juvenile idiopathic arthritis, IgA nephropathy, cutaneous lupus erythematosus, and autoimmune pulmonary disease in the setting of CGD. The presence and type of autoimmune disease have important treatment implications for patients with CGD.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Autoimmune Diseases / etiology*
  • Autoimmune Diseases / pathology
  • Autoimmune Diseases / therapy
  • Female
  • Granulomatous Disease, Chronic / complications*
  • Granulomatous Disease, Chronic / pathology
  • Granulomatous Disease, Chronic / therapy
  • Humans
  • Lung Diseases / etiology*
  • Lung Diseases / pathology
  • Lung Diseases / therapy
  • Male
  • Pericardial Effusion / etiology*
  • Pericardial Effusion / pathology
  • Pericardial Effusion / therapy
  • Risk Factors