The TPR snap helix: a novel protein repeat motif from mitosis to transcription

Trends Biochem Sci. 1991 May;16(5):173-7. doi: 10.1016/0968-0004(91)90070-c.


The recently discovered TPR gene family encodes a diverse group of proteins that function in mitosis, transcription, splicing, protein import and neurogenesis. These multi-domain proteins all contain tandemly arranged repeats of a 34-amino acid motif that are presumed to form helix-turn structures, each with a 'knob' and 'hole', acting as helix-associating domains.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • DNA-Binding Proteins
  • Drosophila
  • Fungal Proteins / genetics*
  • Genes, Fungal / genetics*
  • Genes, Fungal / physiology
  • Mitosis / physiology*
  • Molecular Sequence Data
  • Protein Conformation
  • Repetitive Sequences, Nucleic Acid*
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / physiology
  • Sequence Homology, Nucleic Acid
  • Transcription, Genetic / physiology*


  • DNA-Binding Proteins
  • Fungal Proteins