High-molecular-weight adiponectin and leptin levels in cord blood are associated with anthropometric measurements at birth

Horm Res. 2008;70(5):268-72. doi: 10.1159/000157872. Epub 2008 Sep 30.


Aims: High-molecular-weight adiponectin (HMW-ad) is an active form of adiponectin. No information is available with respect to HMW-ad in neonates. The aims of this study were to examine whether HMW-ad is present in cord blood, to define the association between the concentrations of cord blood HMW-ad and leptin, and their correlation with anthropometric measurements of term neonates at birth.

Methods: Venous cord blood samples were obtained from 135 term healthy neonates (birth weight 2,261-4,164 g) born at Showa University Hospital. Total adiponectin (T-ad), HMW-ad and leptin levels were measured by ELISA.

Results: HMW-ad levels were 14.9 +/- 5.8 microg/ml and the ratio of HMW-ad to T-ad was 0.49 +/- 0.15. In a multiple regression analysis, cord blood HMW-ad levels were a significant predictor of birth weight and birth length, and leptin level was a significant predictor of birth weight and birth weight to body length ratio. There was a significant relationship between concentrations of HMW-ad and leptin controlling for sex, gestational age and birth weight.

Conclusion: These results show that HMW-ad exists as a half of T-ad in the cord blood. Leptin and HMW-ad may regulate synergistically fetal growth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood*
  • Birth Weight
  • Body Height
  • Female
  • Fetal Blood / chemistry*
  • Fetal Development / physiology
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Leptin / blood*
  • Male
  • Molecular Weight
  • Pregnancy


  • Adiponectin
  • Leptin