The vasopressin and copeptin response in patients with vasodilatory shock after cardiac surgery: a prospective, controlled study

Intensive Care Med. 2009 Mar;35(3):489-97. doi: 10.1007/s00134-008-1279-1. Epub 2008 Sep 30.


Objective: To evaluate arginine vasopressin (AVP) and copeptin plasma concentrations in patients with vasodilatory shock after cardiac surgery.

Design: Prospective, controlled, clinical study.

Setting: Surgical intensive care unit and cardiac surgery ward in a tertiary university teaching hospital.

Patients and participants: Thirty-three critically ill patients with vasodilatory shock after cardiac surgery and ten control patients undergoing uncomplicated aorto-coronary bypass surgery.

Measurements and results: Hemodynamic, laboratory and clinical data were recorded daily in all patients during the first 7 days after cardiac surgery. At the same time, points blood was withdrawn to determine plasma concentrations of AVP (radioimmunoassay) and copeptin (immunoluminometric assy). Standard tests, a mixed effects model and regression analyses were used for statistical analysis. The course of AVP was significantly different between groups (P < 0.001). While AVP concentrations were lower in the study group on the first postoperative day, they were higher than that in the control group from postoperative day 3 on. There was no difference in the postoperative AVP response between study patients with or without chronic angiotensin-converting enzyme inhibitor therapy. Except during continuous veno-venous hemofiltration, AVP and copeptin correlated significantly with each other (P < 0.001; r = 0.749).

Conclusions: The AVP response to cardiac surgery is significantly different between patients with vasodilatory shock and patients undergoing uncomplicated aorto-coronary bypass surgery. Although no causative relationship between AVP concentrations and cardiovascular instability can be drawn from these results, our data support the hypothesis that inadequately low AVP plasma levels contribute to the failure to restore vascular tone in vasodilatory shock after cardiac surgery.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cardiac Surgical Procedures*
  • Cardiopulmonary Bypass
  • Drug Therapy, Combination
  • Female
  • Glycopeptides / pharmacology*
  • Glycopeptides / therapeutic use*
  • Humans
  • Male
  • Postoperative Complications*
  • Prospective Studies
  • Shock / drug therapy*
  • Vasoconstrictor Agents / pharmacology*
  • Vasoconstrictor Agents / therapeutic use*
  • Vasodilation / drug effects*
  • Vasopressins / pharmacology*
  • Vasopressins / therapeutic use*


  • Glycopeptides
  • Vasoconstrictor Agents
  • copeptins
  • Vasopressins