CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinase domain

Yeast. 1991 Apr;7(3):265-73. doi: 10.1002/yea.320070308.

Abstract

The cell division cycle gene CDC15 is essential for the late nuclear division in the yeast Saccharomyces cerevisiae. The amino acid sequence of the 974 amino acids/110 kDa CDC15 gene product, as deduced from the nucleotide sequence, includes an aminoterminal protein kinase domain which contains a primary sequence mosaic showing patterns specific for protein serine/threonine kinases besides those for protein tyrosine kinases. Many protein kinases non-essential for growth are known. CDC15 represents an essential protein kinase like CDC7 and CDC28. A carboxyterminal deletion of 32 amino acids renders the protein inactive.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Cycle / genetics*
  • DNA, Fungal / chemistry*
  • Molecular Sequence Data
  • Mutagenesis
  • Open Reading Frames
  • Plasmids
  • Protein Kinases / chemistry
  • Protein Kinases / genetics*
  • Restriction Mapping
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / genetics*
  • TATA Box

Substances

  • DNA, Fungal
  • Protein Kinases

Associated data

  • GENBANK/S57884
  • GENBANK/S64911
  • GENBANK/S64912
  • GENBANK/S64914
  • GENBANK/S64915
  • GENBANK/S70503
  • GENBANK/S70506
  • GENBANK/S70508
  • GENBANK/S76265
  • GENBANK/X60056