Suicide on the paternal and maternal sides of depressed patients with a lifetime history of attempted suicide

Acta Psychiatr Scand. 1991 Jun;83(6):417-9. doi: 10.1111/j.1600-0447.1991.tb05567.x.


The computational model of Slater, based on the analysis of ancestral secondary cases on the paternal and maternal sides of the subjects, was applied to depressed patients with a lifetime history of attempted suicide, either violent or nonviolent, in order to investigate possible modes of transmission of suicidal behavior. Among 549 patients, 15 had 2 or more ascendant first- and second-degree relatives who committed suicide. The results of the distribution of these cases were compatible with polygenic inheritance of suicidal behavior in depressed patients with a history of attempted suicide. In patients using violent methods, a significantly greater loading of ancestral secondary cases of suicide was observed on the maternal side and, in the nonviolent attempter group, on the paternal side.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bipolar Disorder / genetics*
  • Bipolar Disorder / psychology
  • Child of Impaired Parents / psychology*
  • Depressive Disorder / genetics*
  • Depressive Disorder / psychology
  • Female
  • Genes, Dominant / genetics
  • Humans
  • Male
  • Maternal Deprivation
  • Middle Aged
  • Models, Genetic
  • Paternal Deprivation
  • Personality Development*
  • Risk Factors
  • Social Environment*
  • Suicide / psychology*
  • Suicide, Attempted / psychology*
  • Violence