Dietary calcium and vitamin D intakes in childhood and throughout adulthood and mammographic density in a British birth cohort

Br J Cancer. 2008 Nov 4;99(9):1539-43. doi: 10.1038/sj.bjc.6604697. Epub 2008 Sep 30.


We examined the role of dietary calcium and vitamin D intakes in childhood and throughout adulthood in relation to mammographic density using data from a nationally representative cohort of 1161 women followed up since their birth in 1946. Dietary intakes at the age of 4 years were determined by 24-h recalls and at the ages of 36, 43 and 53 years by 5-day food records. After adjusting for known risk factors and confounders, no evidence of a relationship between dietary calcium or vitamin D intakes and mammographic density approximately at the age of 50 years was found, except for a cross-sectional relationship between dietary calcium intake at the age of 53 years and breast density in women who were post-menopausal at the time of mammography, with those in the top fifth of the distribution of calcium intake having a 0.53 s.d. lower percent breast density than those in the lowest fifth (P-value <0.01 for linear trend).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Calcium, Dietary / administration & dosage*
  • Child, Preschool
  • Cohort Studies
  • Female
  • Humans
  • Mammography*
  • Middle Aged
  • Vitamin D / administration & dosage*


  • Calcium, Dietary
  • Vitamin D