The metabolic syndrome, diabetes and lung dysfunction

Diabetes Metab. 2008 Nov;34(5):447-54. doi: 10.1016/j.diabet.2008.08.001. Epub 2008 Sep 30.


Sleep-disordered breathing and sleep apnoea are conditions frequently associated with comorbidity, including obesity, diabetes, hypertension, insulin resistance (metabolic syndrome) and cardiovascular disease. The diabetic state (type 1 and type 2 diabetes) may be associated to diminished lung function and, in particular, decreased vital capacity, and the association between chronic obstructive pulmonary disease (COPD) and type 2 diabetes may be due to a shared inflammatory process. Also, the alteration in circulating endothelial progenitor cells found in respiratory disease, the metabolic syndrome and cardiovascular disease reflect a common condition of endothelial dysfunction.

Publication types

  • Review

MeSH terms

  • Diabetes Complications / physiopathology
  • Diabetes Mellitus / physiopathology*
  • Diabetes Mellitus, Type 1 / physiopathology
  • Diabetes Mellitus, Type 2 / physiopathology
  • Humans
  • Inflammation / physiopathology
  • Lung / physiopathology*
  • Lung Diseases / physiopathology*
  • Metabolic Syndrome / physiopathology*
  • Pulmonary Disease, Chronic Obstructive / physiopathology
  • Sleep Apnea Syndromes / physiopathology
  • Sleep Wake Disorders / physiopathology