Elevated medial-frontal cerebral blood flow in obsessive-compulsive patients: a SPECT study

Am J Psychiatry. 1991 Sep;148(9):1240-2. doi: 10.1176/ajp.148.9.1240.


Regional cerebral blood flow was measured with single photon emission computed tomography in 10 obsessive-compulsive patients and eight comparison subjects. The patients had a significantly higher ratio of medial-frontal to whole cortex blood flow; this was unrelated to symptom severity but was correlated negatively with anxiety. No differences in orbital-frontal blood flow were found.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Anxiety / physiopathology
  • Cerebral Cortex / blood supply
  • Cerebral Cortex / physiopathology
  • Cerebrovascular Circulation*
  • Female
  • Frontal Lobe / blood supply*
  • Frontal Lobe / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Obsessive-Compulsive Disorder / physiopathology*
  • Organotechnetium Compounds
  • Oximes
  • Technetium Tc 99m Exametazime
  • Tomography, Emission-Computed, Single-Photon*


  • Organotechnetium Compounds
  • Oximes
  • Technetium Tc 99m Exametazime