Effects of fluoxetine on regional cerebral blood flow in obsessive-compulsive patients

Am J Psychiatry. 1991 Sep;148(9):1243-5. doi: 10.1176/ajp.148.9.1243.


Six drug-free obsessive-compulsive patients were given single photon emission computerized tomography scans before and during treatment with fluoxetine. The treatment significantly reduced the patients' "hyperfrontality," as determined by the ratio between medial-frontal and whole cerebral cortex blood flow, and significantly lowered ratings of obsessive-compulsive and anxiety symptoms.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Anxiety / drug therapy
  • Anxiety / psychology
  • Cerebral Cortex / blood supply
  • Cerebrovascular Circulation / drug effects*
  • Female
  • Fluoxetine / pharmacology*
  • Fluoxetine / therapeutic use
  • Frontal Lobe / blood supply*
  • Frontal Lobe / drug effects
  • Humans
  • Male
  • Obsessive-Compulsive Disorder / drug therapy*
  • Obsessive-Compulsive Disorder / psychology
  • Tomography, Emission-Computed, Single-Photon


  • Fluoxetine