Abstract
Six drug-free obsessive-compulsive patients were given single photon emission computerized tomography scans before and during treatment with fluoxetine. The treatment significantly reduced the patients' "hyperfrontality," as determined by the ratio between medial-frontal and whole cerebral cortex blood flow, and significantly lowered ratings of obsessive-compulsive and anxiety symptoms.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Anxiety / drug therapy
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Anxiety / psychology
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Cerebral Cortex / blood supply
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Cerebrovascular Circulation / drug effects*
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Female
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Fluoxetine / pharmacology*
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Fluoxetine / therapeutic use
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Frontal Lobe / blood supply*
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Frontal Lobe / drug effects
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Humans
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Male
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Obsessive-Compulsive Disorder / drug therapy*
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Obsessive-Compulsive Disorder / psychology
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Tomography, Emission-Computed, Single-Photon