Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR-gamma, GLUT4 and LPL in ob/ob mice

Phytother Res. 2009 Feb;23(2):220-5. doi: 10.1002/ptr.2593.


The antiobesity effect of wild ginseng (WG; Panax ginseng C.A. Meyer) in male obese leptin-deficient (B6.V-Lepob, 'ob/ob') mice was evaluated. WG was administered orally to mice at doses of 100 mg/kg and 200 mg/kg daily for 4 weeks. The WG-treated ob/ob mice showed a loss of body weight and a decrease in blood glucose levels compared with control mice. WG regulated the mRNA expression level especially, it increased peroxisome proliferators-activated receptors-gamma (PPAR-gamma) and lipoprotein lipase (LPL) in adipose tissue, as well as glucose transporter 4 (GLUT4) and insulin receptor (IR) in the skeletal muscle and liver. Taken together, these results suggest that WG may play a vital role in the antiobesity effect in ob/ob mice; this has importance in insulin sensitivity. This may prove to be of clinical importance in improving the management of obesity and related metabolic syndromes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / drug effects
  • Animals
  • Anti-Obesity Agents / pharmacology*
  • Blood Glucose / drug effects
  • Body Weight / drug effects
  • Glucose Transporter Type 4 / metabolism*
  • Leptin / deficiency
  • Lipoprotein Lipase / metabolism*
  • Liver / metabolism
  • Male
  • Mice
  • Muscle, Skeletal / metabolism
  • Obesity / drug therapy
  • PPAR gamma / metabolism*
  • Panax / chemistry*
  • Receptor, Insulin / metabolism


  • Anti-Obesity Agents
  • Blood Glucose
  • Glucose Transporter Type 4
  • Leptin
  • PPAR gamma
  • Slc2a4 protein, mouse
  • Receptor, Insulin
  • Lipoprotein Lipase