KRAS mutations: an old oncogene becomes a new predictive biomarker

J Mol Diagn. 2008 Nov;10(6):493-5. doi: 10.2353/jmoldx.2008.080105. Epub 2008 Oct 2.

Abstract

This commentary highlights a novel assay for detection of mutations in KRAS, which have recently emerged as a useful negative predictive biomarker.

MeSH terms

  • Biomarkers / metabolism*
  • ErbB Receptors / genetics
  • ErbB Receptors / metabolism
  • Humans
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Oncogenes*
  • Proto-Oncogene Proteins p21(ras)
  • Proto-Oncogene Proteins* / genetics
  • Proto-Oncogene Proteins* / metabolism
  • ras Proteins* / genetics
  • ras Proteins* / metabolism

Substances

  • Biomarkers
  • KRAS protein, human
  • Proto-Oncogene Proteins
  • ErbB Receptors
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins