Antigenic mimicry of the HIV envelope by AIDS-associated pathogens

AIDS. 2008 Oct 18;22(16):2214-7. doi: 10.1097/QAD.0b013e328314b5df.


Only one broadly neutralizing anti-HIV antibody, 2G12, recognises the envelope sugars of HIV. In the present study, we show that 2G12 also recognises Candida albicans and Candida tropicalis with high affinity (11 nmol/l) through a carbohydrate-dependent interaction (50% inhibitory concentration for D-fructose, 12 mmol/l). This is the first report of a neutralizing HIV antibody displaying cross-reactivity with another pathogen, revealing that the carbohydrate neutralization determinant of HIV, defined by 2G12, is more widespread amongst immunogenic, microbial surfaces than previously recognized.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal / immunology
  • Antigens, Fungal / immunology
  • Broadly Neutralizing Antibodies
  • Candida / immunology*
  • Cross Reactions
  • HIV Antibodies
  • HIV Envelope Protein gp120 / immunology*
  • Humans
  • Molecular Mimicry*


  • 2G12 monoclonal antibody
  • Antibodies, Monoclonal
  • Antigens, Fungal
  • Broadly Neutralizing Antibodies
  • HIV Antibodies
  • HIV Envelope Protein gp120