Progress in genetic studies of pain and analgesia

Annu Rev Pharmacol Toxicol. 2009;49:97-121. doi: 10.1146/annurev-pharmtox-061008-103222.


Interindividual variability in pain sensitivity and the response to analgesic manipulations remains a considerable clinical challenge as well as an area of intense scientific investigation. Techniques in this field have matured rapidly so that much relevant data have emerged only in the past few years. Our increasing understanding of the genetic mediation of these biological phenomena have nonetheless revealed their surprising complexity. This review provides a comprehensive picture and critical analysis of the field and its prospects.

Publication types

  • Review

MeSH terms

  • Analgesia / trends*
  • Animals
  • Genetic Techniques
  • Humans
  • Pain / genetics*
  • Pain / physiopathology
  • Phenotype
  • Polymorphism, Genetic / genetics