PASS-assisted exploration of antidepressant activity of 1,3,4-trisubstituted-beta-lactam derivatives

Munish Mittal; Rajesh K Goel; Gaurav Bhargava; Mohinder P Mahajan

doi:10.1016/j.bmcl.2008.09.064

PASS-assisted exploration of antidepressant activity of 1,3,4-trisubstituted-beta-lactam derivatives

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5347-9. doi: 10.1016/j.bmcl.2008.09.064. Epub 2008 Sep 20.

Authors

Munish Mittal¹, Rajesh K Goel, Gaurav Bhargava, Mohinder P Mahajan

Affiliation

¹ Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab 147002, India.

PMID: 18835165
DOI: 10.1016/j.bmcl.2008.09.064

Abstract

Assisted by PASS predictions, the antidepressant activity of 1,3,4-trisubstituted monocyclic beta-lactams in seasonal affective disorders is described.

MeSH terms

Animals
Antidepressive Agents / chemistry*
Antidepressive Agents / pharmacology*
Chemistry, Pharmaceutical / methods*
Computational Biology / methods*
Crystallography, X-Ray
Depression / drug therapy*
Drug Design
Humans
Mice
Models, Chemical
Monobactams / chemistry*
Receptors, GABA / metabolism
Seasonal Affective Disorder / drug therapy*
Serotonin / metabolism
Software

Substances

Antidepressive Agents
Monobactams
Receptors, GABA
Serotonin