Effects of the whole-body cryotherapy on NTproBNP, hsCRP and troponin I in athletes

J Sci Med Sport. 2009 Nov;12(6):609-10. doi: 10.1016/j.jsams.2008.06.004. Epub 2008 Oct 2.


Whole-body cryotherapy refers to brief exposure to very cold air for treating symptoms of various illnesses. In sports medicine, whole-body cryotherapy is administered to improve recovery from muscular trauma. As specific studies are lacking, we measured cardiac markers in 10 top-level rugby players of the Italian National team before and after a 1-week course of daily sessions of whole-body cryotherapy. All subjects continued with the same training workload as that of the previous weeks. N-terminal pro B-type natriuretic peptide (NTproBNP) levels increased but remained within the normal range, whilst troponin I (TnI) and high sensitivity C-reactive protein (hsCRP) were unchanged. Whole-body cryotherapy did not impair cardiac function in this sample of elite athletes.

MeSH terms

  • Adult
  • C-Reactive Protein / metabolism*
  • Cryotherapy*
  • Football / injuries*
  • Humans
  • Male
  • Muscle, Skeletal / injuries*
  • Muscle, Skeletal / metabolism
  • Natriuretic Peptide, Brain / blood*
  • Peptide Fragments / blood*
  • Troponin I / blood*
  • Young Adult


  • Peptide Fragments
  • Troponin I
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain
  • C-Reactive Protein