Functional properties of fibronectin in the trabecular meshwork

Exp Eye Res. 2009 Apr;88(4):689-93. doi: 10.1016/j.exer.2008.08.019. Epub 2008 Sep 18.


Fibronectin plays a number of important roles in the extracellular matrix (ECM) including providing structural support and signaling cues for cell survival, migration, differentiation, gene expression, growth factor signaling, and cell contractility. In this review, we examine recent findings about the biological and structural properties of fibronectin and discuss how these properties could contribute to the regulation of aqueous humor (AH) outflow in the trabecular meshwork (TM).

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Aqueous Humor / physiology
  • Fibronectins / chemistry
  • Fibronectins / physiology*
  • Humans
  • Receptors, Fibronectin / physiology
  • Signal Transduction / physiology
  • Structure-Activity Relationship
  • Trabecular Meshwork / physiology*


  • Fibronectins
  • Receptors, Fibronectin