p53 family in development

Mech Dev. Nov-Dec 2008;125(11-12):919-31. doi: 10.1016/j.mod.2008.09.003. Epub 2008 Sep 20.

Abstract

The p53 family network is a unique cellular processor that integrates information from various pathways and determines cellular choices between proliferation, replication arrest/repair, differentiation, senescence, or apoptosis. The most studied role of the p53 family is the regulation of stress response and tumor suppression. By removing damaged cells from the proliferating pool, p53 family members preserve the integrity of the genome. In addition to this well recognized role, recent data implicate the p53 protein family in a broader role of controlling cell proliferation, differentiation and death. Members of the p53 protein family with opposing activity perform coordination of these processes. Imbalance of p53 protein family may contribute to a significant proportion of congenital developmental abnormalities in humans.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Cell Death
  • Cell Differentiation
  • Cell Proliferation
  • Congenital Abnormalities
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology
  • Gene Expression Regulation, Developmental*
  • Genes, p53*
  • Humans
  • Models, Biological
  • Nuclear Proteins / genetics
  • Nuclear Proteins / physiology
  • Signal Transduction
  • Trans-Activators / genetics
  • Trans-Activators / physiology
  • Transcription Factors
  • Tumor Protein p73
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / physiology*
  • Tumor Suppressor Proteins / genetics
  • Tumor Suppressor Proteins / physiology

Substances

  • DNA-Binding Proteins
  • Nuclear Proteins
  • TP63 protein, human
  • Trans-Activators
  • Transcription Factors
  • Tumor Protein p73
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins