Relationship between CD107a expression and cytotoxic activity

Cell Immunol. 2009;254(2):149-54. doi: 10.1016/j.cellimm.2008.08.007. Epub 2008 Oct 5.


NK cells play important roles in innate immunity against tumors and infections of the host. Studies show that CD107a (LAMP-1) may be a marker for degranulation of NK and activated CD8+ T cells. In our study, the relationship between the expression of CD107a, cytokine secretion and cytotoxic activity in CD56+ NK, CD8+ T cells and lymphocytes has been determined after various stimuli. Effector cells from PBMCs of healthy subjects were isolated and K562 cell line was used as target of cytotoxicity. IL-2 stimulation resulted in a significant increase of CD107a expression in CD56+ NK, CD8+ T cells and lymphocytes. Increased expression of CD107a after IL-2 stimulation of NK cells was parallel to the increase of cytotoxicity. Our results suggest that CD107a expression may be a sensitive marker for the cytotoxic activity determination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cell Line, Tumor
  • Cytotoxicity, Immunologic / immunology*
  • Female
  • Humans
  • Interleukin-10 / pharmacology
  • Interleukin-2 / pharmacology
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / metabolism
  • Lysosomal-Associated Membrane Protein 1 / genetics
  • Lysosomal-Associated Membrane Protein 1 / immunology*
  • Male
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism


  • Interleukin-2
  • Lysosomal-Associated Membrane Protein 1
  • Interleukin-10