Differential effects of two isoenergetic meals rich in saturated or monounsaturated fat on endothelial function in subjects with type 2 diabetes

Diabetes Care. 2008 Dec;31(12):2276-8. doi: 10.2337/dc08-0924. Epub 2008 Oct 3.


Objective: To examine the acute effects of consumption of monounsaturated (MUFAs) and saturated fatty acids (SAFAs) on endothelial function in subjects with type 2 diabetes.

Research design and methods: A total of 33 participants were examined after consumption of two different isocaloric meals: one rich in MUFA and one rich in SAFA, in the form of extra-virgin olive oil and butter, respectively. Endothelial function was assessed by determination of flow-mediated dilatation (FMD).

Results: FMD did not change significantly after the MUFA-rich meal but declined after the SAFA-rich meal. The FMD during the experiment, expressed as incremental area under the curve, increased after the MUFA-rich meal by 5.2 +/- 2.5% and decreased after the SAFA-rich meal by 16.7 +/- 6.0% (Delta = -11.5 +/- 6.4%; P = 0.008).

Conclusions: Consumption of an SAFA-rich meal is harmful for the endothelium, while a MUFA-rich meal does not impair endothelial function in subjects with type 2 diabetes.

MeSH terms

  • Aged
  • Butter
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Dietary Fats, Unsaturated / administration & dosage
  • Dietary Fats, Unsaturated / pharmacology*
  • Endothelium, Vascular / drug effects*
  • Fatty Acids / administration & dosage
  • Fatty Acids / pharmacology*
  • Fatty Acids, Monounsaturated / administration & dosage
  • Fatty Acids, Monounsaturated / pharmacology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Olive Oil
  • Plant Oils
  • Vasodilation / drug effects*


  • Dietary Fats, Unsaturated
  • Fatty Acids
  • Fatty Acids, Monounsaturated
  • Olive Oil
  • Plant Oils
  • Butter