Cellular aging and senescence

Curr Opin Cell Biol. 1991 Apr;3(2):230-4. doi: 10.1016/0955-0674(91)90144-n.


Differentiated eukaryotic cells have only a finite capacity for cell division. This limitation is thought to be a cellular manifestation of organismal aging, and a restraint to tumor progression. The molecular basis for cellular senescence is not known, but a molecular framework for understanding this phenomenon has recently been established.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division
  • Cell Survival / genetics*
  • Humans