The microRNA-200 family regulates epithelial to mesenchymal transition

ScientificWorldJournal. 2008 Sep 21;8:901-4. doi: 10.1100/tsw.2008.115.

Abstract

Epithelial-mesenchymal transition (EMT) is implicated in metastasis initiation and has recently been shown to be regulated by the miRNA-200 family and miR-205. Expression of these miRNAs was lost in invasive breast cancer cell lines displaying mesenchymal-like morphology suggesting these microRNAs may play a role in cancer metastasis.

MeSH terms

  • Animals
  • Cell Line
  • Dogs
  • Epithelium / physiology
  • Homeodomain Proteins / physiology
  • Humans
  • Mesoderm / physiology
  • MicroRNAs / physiology*
  • Neoplasm Metastasis / physiopathology
  • Neoplasms / etiology*
  • Nerve Tissue Proteins / physiology
  • RNA-Binding Proteins / physiology
  • Transcription Factors / physiology
  • Zinc Finger E-box-Binding Homeobox 1

Substances

  • GEMIN2 protein, human
  • Homeodomain Proteins
  • MicroRNAs
  • Nerve Tissue Proteins
  • RNA-Binding Proteins
  • Transcription Factors
  • ZEB1 protein, human
  • Zinc Finger E-box-Binding Homeobox 1