Multi-modal imaging predicts memory performance in normal aging and cognitive decline

Neurobiol Aging. 2010 Jul;31(7):1107-21. doi: 10.1016/j.neurobiolaging.2008.08.013. Epub 2008 Oct 5.


This study (n=161) related morphometric MR imaging, FDG-PET and APOE genotype to memory scores in normal controls (NC), mild cognitive impairment (MCI) and Alzheimer's disease (AD). Stepwise regression analyses focused on morphometric and metabolic characteristics of the episodic memory network: hippocampus, entorhinal, parahippocampal, retrosplenial, posterior cingulate, precuneus, inferior parietal, and lateral orbitofrontal cortices. In NC, hippocampal metabolism predicted learning; entorhinal metabolism predicted recognition; and hippocampal metabolism predicted recall. In MCI, thickness of the entorhinal and precuneus cortices predicted learning, while parahippocampal metabolism predicted recognition. In AD, posterior cingulate cortical thickness predicted learning, while APOE genotype predicted recognition. In the total sample, hippocampal volume and metabolism, cortical thickness of the precuneus, and inferior parietal metabolism predicted learning; hippocampal volume and metabolism, parahippocampal thickness and APOE genotype predicted recognition. Imaging methods appear complementary and differentially sensitive to memory in health and disease. Medial temporal and parietal metabolism and morphometry best explained memory variance. Medial temporal characteristics were related to learning, recall and recognition, while parietal structures only predicted learning.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / metabolism
  • Aging / physiology*
  • Aging / psychology*
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / metabolism
  • Cognition Disorders / psychology
  • Early Diagnosis
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory / physiology*
  • Memory Disorders / diagnosis*
  • Memory Disorders / metabolism
  • Memory Disorders / psychology
  • Mental Recall / physiology*
  • Middle Aged
  • Positron-Emission Tomography / methods
  • Predictive Value of Tests
  • Prognosis


  • Fluorodeoxyglucose F18