RecA protein in the SOS response: milestones and mysteries

Biochimie. Feb-Mar 1991;73(2-3):133-41. doi: 10.1016/0300-9084(91)90196-8.


The role of RecA protein in the SOS response of Escherichia coli is traced from the isolation of the first recA mutant to our current understanding of the scope and regulation of this DNA damage-inducible system. In addition, possible RecA protein activities that may be essential in the expression of several SOS phenotypes (stable DNA replication, DNA replication recovery, SOS mutagenesis and RecA association with the cell membrane) are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • DNA Repair
  • DNA Replication
  • Escherichia coli / genetics*
  • Mutagenesis
  • Rec A Recombinases / genetics
  • Rec A Recombinases / metabolism*
  • SOS Response, Genetics / physiology*


  • Rec A Recombinases