Comparative Genomics of the Neglected Human Malaria Parasite Plasmodium Vivax

Nature. 2008 Oct 9;455(7214):757-63. doi: 10.1038/nature07327.

Abstract

The human malaria parasite Plasmodium vivax is responsible for 25-40% of the approximately 515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Artemisinins / metabolism
  • Artemisinins / pharmacology
  • Atovaquone / metabolism
  • Atovaquone / pharmacology
  • Cell Nucleus / genetics
  • Chromosomes / genetics
  • Conserved Sequence / genetics
  • Erythrocytes / parasitology
  • Evolution, Molecular
  • Genome, Protozoan / genetics*
  • Genomics*
  • Haplorhini / parasitology
  • Humans
  • Isochores / genetics
  • Ligands
  • Malaria, Vivax / metabolism
  • Malaria, Vivax / parasitology*
  • Multigene Family
  • Plasmodium vivax / drug effects
  • Plasmodium vivax / genetics*
  • Plasmodium vivax / pathogenicity
  • Plasmodium vivax / physiology
  • Sequence Analysis, DNA
  • Species Specificity
  • Synteny / genetics

Substances

  • Artemisinins
  • Isochores
  • Ligands
  • artemisinine
  • Atovaquone