Pharmacokinetic and pharmacodynamic study of interaction of Rhodiola rosea SHR-5 extract with warfarin and theophylline in rats

Phytother Res. 2009 Mar;23(3):351-7. doi: 10.1002/ptr.2631.


Significant pharmacokinetic/pharmacodynamic interactions between various herbal products and drugs being substrates of cytochrome P450 have recently been reported. The aim of this study was to determine whether Rhodiola rosea SHR-5 extract interacts with warfarin and theophylline when administered concomitantly. Thus, concomitant treatment of rats with theophylline and SHR-5 did not give rise to significant effects on the pharmacokinetics of theophylline. Simultaneous administration of SHR-5 and warfarin did not alter significantly the pharmacokinetics or the anticoagulant activity of warfarin. It is concluded that SHR-5 might be of value in the treatment of patients with mild or moderate depression, and that its interaction with co-administered drugs is likely to be negligible.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticoagulants / blood
  • Anticoagulants / pharmacokinetics*
  • Anticoagulants / pharmacology
  • Herb-Drug Interactions*
  • Male
  • Plant Extracts / pharmacokinetics*
  • Plant Extracts / pharmacology
  • Plants, Medicinal
  • Rats
  • Rats, Wistar
  • Rhodiola / chemistry*
  • Theophylline / blood
  • Theophylline / pharmacokinetics*
  • Theophylline / pharmacology
  • Warfarin / blood
  • Warfarin / pharmacokinetics*
  • Warfarin / pharmacology


  • Anticoagulants
  • Plant Extracts
  • Warfarin
  • Theophylline