Abstract
The screening of a commercially available library of compounds has proved a successful strategy for the identification of a lead compound in a drug discovery programme. Here, we analysed 880 off-patent drugs, which initially comprised the Prestwick Chemical library, as sources of bacterial endotoxin neutralizers. We identified 3,3',5-triiodo-thyroacetic acid (tiratricol) as a non-antibacterial compound that neutralizes the toxic lipopolysaccharide.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / pharmacology*
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Cell Line
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Endotoxins / antagonists & inhibitors*
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Escherichia coli / drug effects
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Lipopolysaccharides / pharmacology*
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Mice
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Structure-Activity Relationship
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Triiodothyronine / analogs & derivatives*
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Triiodothyronine / chemical synthesis
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Triiodothyronine / chemistry
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Triiodothyronine / pharmacology
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Tumor Necrosis Factor-alpha / biosynthesis*
Substances
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Anti-Bacterial Agents
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Endotoxins
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Lipopolysaccharides
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Tumor Necrosis Factor-alpha
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Triiodothyronine
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3,3',5-triiodothyroacetic acid