Distribution of serotypes and antibiotic resistance of invasive pneumococcal disease isolates among children aged 5 years and under in Saudi Arabia (2000-2004)

Clin Microbiol Infect. 2008 Sep;14(9):876-9. doi: 10.1111/j.1469-0691.2008.02058.x.


To determine vaccine coverage of invasive pneumococcal disease (IPD) in Saudi Arabian children aged 5 years and under, 350 IPD isolates were tested for antibiotic susceptibility. Of these 46%, 42% and 12% were penicillin-sensitive, pencillinintermediate, and penicillin-resistant, respectively. Rates of resistance to erythromycin and cefotaxime were 26% and 6%, respectively. The potential serotype coverage of the PCV7 vaccine in Saudi Arabia among children <5 years of age is 62%, and vaccine coverage significantly improved in children <2 years of age, to reach 83% against IPD isolates. PCV7 is expected to have a substantial impact on the burden of invasive and antibiotic-resistant pneumococcal disease in Saudi Arabia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Child, Preschool
  • Drug Resistance, Microbial*
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Humans
  • Infant
  • Meningococcal Vaccines / immunology
  • Microbial Sensitivity Tests
  • Pneumococcal Infections / microbiology*
  • Pneumococcal Vaccines / immunology
  • Saudi Arabia
  • Serotyping
  • Streptococcus pneumoniae / classification*
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / isolation & purification


  • Anti-Bacterial Agents
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Meningococcal Vaccines
  • Pneumococcal Vaccines