Regulation of vitamin D homeostasis: implications for the immune system

Nutr Rev. 2008 Oct;66(10 Suppl 2):S125-34. doi: 10.1111/j.1753-4887.2008.00096.x.


Vitamin D homeostasis in the immune system is the focus of this review. The production of both the activating (25- and 1alpha-hydroxylase) and the metabolizing (24-hydroxylase) enzymes by cells of the immune system itself, indicates that 1,25(OH)(2)D(3) can be produced locally in immune reaction sites. Moreover, the strict regulation of these enzymes by immune signals is highly suggestive for an autocrine/paracrine role in the immune system, and opens new treatment possibilities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / metabolism*
  • Calcitriol / metabolism
  • Endocrine System / physiology*
  • Humans
  • Immunity, Cellular / drug effects*
  • Immunity, Cellular / physiology
  • Receptors, Calcitriol / metabolism
  • Receptors, Calcitriol / physiology*
  • Vitamin D* / analogs & derivatives
  • Vitamin D* / immunology
  • Vitamin D* / physiology


  • Receptors, Calcitriol
  • Vitamin D
  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
  • Calcitriol